Endothelin 2

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Endothelin 2
Identifiers
Symbols EDN2 ; ET2; PPET2
External IDs OMIM131241 MGI95284 HomoloGene1477 GeneCards: EDN2 Gene
Orthologs
Species Human Mouse
Entrez 1907 13615
Ensembl ENSG00000127129 ENSMUSG00000028635
UniProt P20800 P22389
RefSeq (mRNA) NM_001956 NM_007902
RefSeq (protein) NP_001947 NP_031928
Location (UCSC) Chr 1:
41.94 – 41.95 Mb
Chr 4:
120.16 – 120.17 Mb
PubMed search [1] [2]

Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene.[1]

Function[edit]

Endothelin 2 is a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.[1]

References[edit]

Further reading[edit]