Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the vacuole. Mycobacterium tuberculosis is known to inhibit the recruitment of EEA1 to the phagosomal membrane through CamKII.Legionella pneumophila also prevents EEA1 recruitment through a currently unknown mechanism. Interestingly, the related pathogen Legionella longbeachae recruits EEA1 and appears to replicate within a modified early endosome.
^Barysch, S. V.; Aggarwal, S.; Jahn, R.; Rizzoli, S. O. (2009). "Sorting in early endosomes reveals connections to docking- and fusion-associated factors". Proceedings of the National Academy of Sciences106 (24): 9697. doi:10.1073/pnas.0901444106.edit
^Malik, Z. A.; Thompson, C. R.; Hashimi, S.; Porter, B.; Iyer, S. S.; Kusner, D. J. (2003). "Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase". Journal of immunology (Baltimore, Md. : 1950)170 (6): 2811–2815. PMID12626530.edit
^Urwyler, S.; Nyfeler, Y.; Ragaz, C.; Lee, H.; Mueller, L. N.; Aebersold, R.; Hilbi, H. (2009). "Proteome Analysis of Legionella Vacuoles Purified by Magnetic Immunoseparation Reveals Secretory and Endosomal GTPases". Traffic10 (1): 76–87. doi:10.1111/j.1600-0854.2008.00851.x. PMID18980612.edit