EEF1A2

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Eukaryotic translation elongation factor 1 alpha 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EEF1A2 ; EEF1AL; EF-1-alpha-2; EF1A; HS1; STN; STNL
External IDs OMIM602959 MGI1096317 HomoloGene121568 ChEMBL: 1795122 GeneCards: EEF1A2 Gene
RNA expression pattern
PBB GE EEF1A2 204540 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1917 13628
Ensembl ENSG00000101210 ENSMUSG00000016349
UniProt Q05639 P62631
RefSeq (mRNA) NM_001958 NM_007906
RefSeq (protein) NP_001949 NP_031932
Location (UCSC) Chr 20:
62.12 – 62.13 Mb
Chr 2:
181.15 – 181.16 Mb
PubMed search [1] [2]

Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene.[1][2][3]

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer.[3]

References[edit]

  1. ^ Knudsen SM, Frydenberg J, Clark BF, Leffers H (Sep 1993). "Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha". Eur J Biochem 215 (3): 549–54. doi:10.1111/j.1432-1033.1993.tb18064.x. PMID 8354261. 
  2. ^ Lund A, Knudsen SM, Vissing H, Clark B, Tommerup N (Jan 1997). "Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3". Genomics 36 (2): 359–61. doi:10.1006/geno.1996.0475. PMID 8812466. 
  3. ^ a b "Entrez Gene: EEF1A2 eukaryotic translation elongation factor 1 alpha 2". 

Further reading[edit]