EEF1A2

Eukaryotic translation elongation factor 1 alpha 2
Identifiers
Symbols	EEF1A2; EEF1AL; EF-1-alpha-2; EF1A; FLJ41696; HS1; STN; STNL
External IDs	OMIM: 602959 MGI: 1096317 HomoloGene: 121568 GeneCards: EEF1A2 Gene
Gene Ontology Molecular function • nucleotide binding • translation elongation factor activity • GTPase activity • protein binding • GTP binding • translation factor activity, nucleic acid binding Cellular component • nucleus • cytoplasm • eukaryotic translation elongation factor 1 complex • neuronal cell body Biological process • translation • anti-apoptosis • response to inorganic substance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1917	13628
Ensembl	ENSG00000101210	ENSMUSG00000016349
UniProt	Q05639	P62631
RefSeq (mRNA)	NM_001958	NM_007906.2
RefSeq (protein)	NP_001949	NP_031932.1
Location (UCSC)	Chr 20: 62.12 – 62.13 Mb	Chr 2: 180.88 – 180.89 Mb
PubMed search	[1]	[2]

Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene.

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer.

Further reading

• Lee JM (2004). "The role of protein elongation factor eEF1A2 in ovarian cancer". Reprod. Biol. Endocrinol. 1: 69. doi:10.1186/1477-7827-1-69. PMC 239897. PMID 14588074. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=239897. 
• Beh KJ (1976). "Immunoglobulin class specificity of non-agglutinating antibody produced in cattle following Brucella abortus 45/20 vaccination". Aust. Vet. J. 51 (10): 481–3. doi:10.1111/j.1751-0813.1975.tb02385.x. PMID 812466. 
• Lee S, Ann DK, Wang E (1994). "Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway". Biochem. Biophys. Res. Commun. 203 (3): 1371–7. doi:10.1006/bbrc.1994.2336. PMID 7945283. 
• Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA". J. Biol. Chem. 271 (8): 4201–8. doi:10.1074/jbc.271.8.4201. PMID 8626763. 
• Bischoff C, Kahns S, Lund A et al (2001). "The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity". Genomics 68 (1): 63–70. doi:10.1006/geno.2000.6271. PMID 10950927. 
• Deloukas P, Matthews LH, Ashurst J et al (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• McClatchy DB, Knudsen CR, Clark BF et al (2002). "Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2". J. Biol. Chem. 277 (32): 29268–74. doi:10.1074/jbc.M203081200. PMID 12048193. 
• Anand N, Murthy S, Amann G et al (2002). "Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer". Nat. Genet. 31 (3): 301–5. doi:10.1038/ng904. PMID 12053177. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Bouwmeester T, Bauch A, Ruffner H et al (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rush J, Moritz A, Lee KA et al (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
• Andersen JS, Lam YW, Leung AK et al (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
• Byun HM, Suh D, Jeong Y et al (2005). "Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells". Biochem. Biophys. Res. Commun. 332 (2): 518–23. doi:10.1016/j.bbrc.2005.04.155. PMID 15893736. 
• Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740. 
• Tomlinson VA, Newbery HJ, Wray NR et al (2006). "Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours". BMC Cancer 5: 113. doi:10.1186/1471-2407-5-113. PMC 1236916. PMID 16156888. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1236916. 
• Li R, Wang H, Bekele BN et al (2006). "Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach". Oncogene 25 (18): 2628–35. doi:10.1038/sj.onc.1209289. PMID 16369491.