EEF1B2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Eukaryotic translation elongation factor 1 beta 2
Protein EEF1B2 PDB 1b64.png
PDB rendering based on 1b64.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EEF1B2 ; EEF1B; EEF1B1; EF1B
External IDs OMIM600655 MGI1929520 HomoloGene1480 GeneCards: EEF1B2 Gene
Orthologs
Species Human Mouse
Entrez 1933 55949
Ensembl ENSG00000114942 ENSMUSG00000025967
UniProt P24534 O70251
RefSeq (mRNA) NM_001037663 NM_018796
RefSeq (protein) NP_001032752 NP_061266
Location (UCSC) Chr 2:
207.02 – 207.03 Mb
Chr 1:
63.18 – 63.18 Mb
PubMed search [1] [2]

Elongation factor 1-beta is a protein that in humans is encoded by the EEF1B2 gene.[1][2]

This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR.[2]

Interactions[edit]

EEF1B2 has been shown to interact with EEF1G[3][4] and HARS.[5]

References[edit]

  1. ^ Pizzuti A, Gennarelli M, Novelli G, Colosimo A, Lo Cicero S, Caskey CT, Dallapiccola B (January 1994). "Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X". Biochem Biophys Res Commun 197 (1): 154–62. doi:10.1006/bbrc.1993.2454. PMID 8250921. 
  2. ^ a b "Entrez Gene: EEF1B2 eukaryotic translation elongation factor 1 beta 2". 
  3. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  4. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 
  5. ^ Sang Lee, Jong; Gyu Park Sang; Park Heonyong; Seol Wongi; Lee Sangwon; Kim Sunghoon (February 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. (United States) 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. ISSN 0006-291X. PMID 11829477. 

Further reading[edit]