EFCBP2

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N-terminal EF-hand calcium binding protein 2
Identifiers
Symbols NECAB2 ; EFCBP2
External IDs MGI2152211 HomoloGene62200 GeneCards: NECAB2 Gene
RNA expression pattern
PBB GE EFCBP2 215005 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 54550 117148
Ensembl ENSG00000103154 ENSMUSG00000031837
UniProt Q7Z6G3 Q91ZP9
RefSeq (mRNA) NM_019065 NM_054095
RefSeq (protein) NP_061938 NP_473436
Location (UCSC) Chr 16:
84 – 84.04 Mb
Chr 8:
119.45 – 119.47 Mb
PubMed search [1] [2]

N-terminal EF-hand calcium-binding protein 2 is a protein that in humans is encoded by the NECAB2 gene.[1][2]


Model organisms[edit]

Model organisms have been used in the study of NECAB2 function. A conditional knockout mouse line, called Necab2tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[5]

References[edit]

  1. ^ Sugita S, Ho A, Sudhof TC (Jun 2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471. 
  2. ^ "Entrez Gene: EFCBP2 EF-hand calcium binding protein 2". 
  3. ^ "Salmonella infection data for Necab2". Wellcome Trust Sanger Institute. 
  4. ^ "Citrobacter infection data for Necab2". Wellcome Trust Sanger Institute. 
  5. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  6. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ^ "International Knockout Mouse Consortium". 
  8. ^ "Mouse Genome Informatics". 
  9. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  10. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  11. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  12. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]