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N-terminal EF-hand calcium binding protein 2
Symbols NECAB2 ; EFCBP2
External IDs MGI2152211 HomoloGene62200 GeneCards: NECAB2 Gene
RNA expression pattern
PBB GE EFCBP2 215005 at tn.png
More reference expression data
Species Human Mouse
Entrez 54550 117148
Ensembl ENSG00000103154 ENSMUSG00000031837
UniProt Q7Z6G3 Q91ZP9
RefSeq (mRNA) NM_019065 NM_054095
RefSeq (protein) NP_061938 NP_473436
Location (UCSC) Chr 16:
84 – 84.04 Mb
Chr 8:
119.45 – 119.47 Mb
PubMed search [1] [2]

N-terminal EF-hand calcium-binding protein 2 is a protein that in humans is encoded by the NECAB2 gene.[1][2]

Model organisms[edit]

Model organisms have been used in the study of NECAB2 function. A conditional knockout mouse line, called Necab2tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[5]


  1. ^ Sugita S, Ho A, Sudhof TC (Jun 2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern". Neuroscience 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471. 
  2. ^ "Entrez Gene: EFCBP2 EF-hand calcium binding protein 2". 
  3. ^ "Salmonella infection data for Necab2". Wellcome Trust Sanger Institute. 
  4. ^ "Citrobacter infection data for Necab2". Wellcome Trust Sanger Institute. 
  5. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  6. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ^ "International Knockout Mouse Consortium". 
  8. ^ "Mouse Genome Informatics". 
  9. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  10. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  11. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  12. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]