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EGF containing fibulin-like extracellular matrix protein 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EFEMP2 ; ARCL1B; FBLN4; MBP1; UPH1
External IDs OMIM604633 MGI1891209 HomoloGene32339 GeneCards: EFEMP2 Gene
RNA expression pattern
PBB GE EFEMP2 206580 s at tn.png
PBB GE EFEMP2 209356 x at tn.png
More reference expression data
Species Human Mouse
Entrez 30008 58859
Ensembl ENSG00000172638 ENSMUSG00000024909
UniProt O95967 Q9WVJ9
RefSeq (mRNA) NM_016938 NM_001164352
RefSeq (protein) NP_058634 NP_001157824
Location (UCSC) Chr 11:
65.63 – 65.64 Mb
Chr 19:
5.47 – 5.48 Mb
PubMed search [1] [2]

EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene.[1][2][3]

A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. EFEMP2 (also known as fibulin-4) contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is widely expressed in a range of adult and fetal tissues.[3]


EFEMP2 has been shown to interact with P53.[4]


  1. ^ Giltay R, Timpl R, Kostka G (Feb 2000). "Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4". Matrix Biol 18 (5): 469–80. doi:10.1016/S0945-053X(99)00038-4. PMID 10601734. 
  2. ^ Katsanis N, Venable S, Smith JR, Lupski JR (Sep 2000). "Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13". Hum Genet 106 (1): 66–72. doi:10.1007/s004390051011. PMID 10982184. 
  3. ^ a b "Entrez Gene: EFEMP2 EGF-containing fibulin-like extracellular matrix protein 2". 
  4. ^ Gallagher, W M; Argentini M; Sierra V; Bracco L; Debussche L; Conseiller E (Jun 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene (ENGLAND) 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. ISSN 0950-9232. PMID 10380882. 

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