EFNA2

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Ephrin-A2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EFNA2 ; ELF-1; EPLG6; HEK7-L; LERK-6; LERK6
External IDs OMIM602756 MGI102707 HomoloGene1075 ChEMBL: 1795109 GeneCards: EFNA2 Gene
RNA expression pattern
PBB GE EFNA2 208256 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1943 13637
Ensembl ENSG00000099617 ENSMUSG00000003070
UniProt O43921 P52801
RefSeq (mRNA) NM_001405 NM_007909
RefSeq (protein) NP_001396 NP_031935
Location (UCSC) Chr 19:
1.29 – 1.3 Mb
Chr 10:
80.18 – 80.19 Mb
PubMed search [1] [2]

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.[1]

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.[1]

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