EFNB3

Ephrin-B3
Identifiers
Symbols	EFNB3; EFL6; EPLG8; LERK8
External IDs	OMIM: 602297 MGI: 109196 HomoloGene: 1076 GeneCards: EFNB3 Gene
Gene Ontology Molecular function • transmembrane-ephrin receptor activity • ephrin receptor binding Cellular component • integral to plasma membrane • membrane Biological process • cell-cell signaling • multicellular organismal development • nervous system development • adult walking behavior • axon choice point recognition • cell differentiation • interspecies interaction between organisms • ephrin receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1949	13643
Ensembl	ENSG00000108947	ENSMUSG00000003934
UniProt	Q15768	Q5F221
RefSeq (mRNA)	NM_001406	NM_007911.5
RefSeq (protein)	NP_001397	NP_031937.1
Location (UCSC)	Chr 17: 7.61 – 7.61 Mb	Chr 11: 69.37 – 69.37 Mb
PubMed search	[1]	[2]

Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene.

EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression are particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
• Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033–44. PMID 10207129. 
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol.. International Review of Cytology 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. PMID 10730216. 
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1692797. 
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. 
• Gale NW, Flenniken A, Compton DC, et al. (1996). "Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments". Oncogene 13 (6): 1343–52. PMID 8808709. 
• Ephnomenclaturecommittee, (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
• Bergemann AD, Zhang L, Chiang MK, et al. (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube". Oncogene 16 (4): 471–80. doi:10.1038/sj.onc.1201557. PMID 9484836. 
• Brückner K, Pablo Labrador J, Scheiffele P, et al. (1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron 22 (3): 511–24. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531. 
• Liu W, Ahmad SA, Jung YD, et al. (2002). "Coexpression of ephrin-Bs and their receptors in colon carcinoma". Cancer 94 (4): 934–9. doi:10.1002/cncr.10122. PMID 11920461. 
• Takemoto M, Fukuda T, Sonoda R, et al. (2002). "Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro". Eur. J. Neurosci. 16 (6): 1168–72. doi:10.1046/j.1460-9568.2002.02166.x. PMID 12383247. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.