EHF (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ets homologous factor
Identifiers
Symbols EHF ; ESE3; ESE3B; ESEJ
External IDs OMIM605439 MGI1270840 HomoloGene7301 GeneCards: EHF Gene
RNA expression pattern
PBB GE EHF 219850 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26298 13661
Ensembl ENSG00000135373 ENSMUSG00000012350
UniProt Q9NZC4 O70273
RefSeq (mRNA) NM_001206615 NM_007914
RefSeq (protein) NP_001193544 NP_031940
Location (UCSC) Chr 11:
34.64 – 34.68 Mb
Chr 2:
103.26 – 103.3 Mb
PubMed search [1] [2]

ETS homologous factor is a protein that in humans is encoded by the EHF gene.[1][2]

This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.[2]


Further reading[edit]

{{PBB_Further_reading

Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.

Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).

References

  1. ^ Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH (Nov 1999). "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF". Biochem Biophys Res Commun 264 (1): 119–26. doi:10.1006/bbrc.1999.1493. PMID 10527851. 
  2. ^ a b "Entrez Gene: EHF ets homologous factor". 

| citations =

}}

External links[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.