Eukaryotic translation initiation factor 1 is a protein that in humans is encoded by the EIF1gene.
Mammalian 17-kDa eukaryotic initiation factor, eIF1A (formerly designated eIF-4C), is essential for transfer of the initiator Met-tRNAf (as Met-tRNAf·eIF2·GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA to form the 40 S preinitiation complex (40 S·Met-tRNAf·eIF2·GTP). Furthermore, eIF1A acts catalytically in this reaction to mediate highly efficient transfer of the Met-tRNAf·eIF2·GTP ternary complex to 40 S ribosomal subunits. The 40 S complex formed is free of eIF1A which indicates that its role in 40 S preinitiation complex formation is not to stabilize the binding of Met-tRNAf to 40 S ribosomes. Additionally, the eIF1A-mediated 40 S initiation complex formed in the presence of AUG codon efficiently joins 60 S ribosomal subunits in an eIF5-dependent reaction to form a functional 80 S initiation complex. Though found in some reports, eIF1A probably plays no role either in the subunit joining reaction or in the generation of ribosomal subunits from 80 S ribosomes. The major function of eIF1A is to mediate the transfer of Met-tRNAf to 40 S ribosomal subunits to form the 40 S preinitiation complex.
^Fields C, Adams MD (Feb 1994). "Expressed sequence tags identify a human isolog of the suil translation initiation factor". Biochem Biophys Res Commun198 (1): 288–91. doi:10.1006/bbrc.1994.1040. PMID7904817.
^Sheikh MS, Fernandez-Salas E, Yu M, Hussain A, Dinman JD, Peltz SW, Huang Y, Fornace AJ Jr (Jul 1999). "Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1))". J Biol Chem274 (23): 16487–93. doi:10.1074/jbc.274.23.16487. PMID10347211.
Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res.6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID8889549.CS1 maint: Explicit use of et al. (link)
Lian Z, Pan J, Liu J et al. (1999). "The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis.". Oncogene18 (9): 1677–87. doi:10.1038/sj.onc.1202470. PMID10208429.CS1 maint: Explicit use of et al. (link)
Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci.7 (2): 152–9. doi:10.1007/BF02256622. PMID10754390.
Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol.23 (1): 94–101. doi:10.1038/nbt1046. PMID15592455.CS1 maint: Explicit use of et al. (link)