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Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF2B1 ; EIF2B; EIF2BA
External IDs OMIM606686 MGI2384802 HomoloGene1080 GeneCards: EIF2B1 Gene
RNA expression pattern
PBB GE EIF2B1 201632 at tn.png
More reference expression data
Species Human Mouse
Entrez 1967 209354
Ensembl ENSG00000111361 ENSMUSG00000029388
UniProt Q14232 Q99LC8
RefSeq (mRNA) NM_001414 NM_145371
RefSeq (protein) NP_001405 NP_663346
Location (UCSC) Chr 12:
124.1 – 124.12 Mb
Chr 5:
124.57 – 124.58 Mb
PubMed search [1] [2]

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.[1]


EIF2B1 has been shown to interact with EIF2B5.[2][3]


  1. ^ "Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa". 
  2. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  3. ^ Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531. 

Further reading[edit]