EIF2B2

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Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Identifiers
Symbols EIF2B2 ; EIF-2Bbeta; EIF2B
External IDs OMIM606454 MGI2145118 HomoloGene6507 GeneCards: EIF2B2 Gene
RNA expression pattern
PBB GE EIF2B2 202461 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8892 217715
Ensembl ENSG00000119718 ENSMUSG00000004788
UniProt P49770 Q99LD9
RefSeq (mRNA) NM_014239 NM_145445
RefSeq (protein) NP_055054 NP_663420
Location (UCSC) Chr 14:
75.47 – 75.48 Mb
Chr 12:
85.22 – 85.23 Mb
PubMed search [1] [2]

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.[1][2]

Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.[supplied by OMIM][2]

Interactions[edit]

EIF2B2 has been shown to interact with EIF2B5[3] and NCK1.[4]

References[edit]

  1. ^ Yang W, Hinnebusch AG (December 1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol Cell Biol 16 (11): 6603–16. PMC 231662. PMID 8887689. 
  2. ^ a b "Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa". 
  3. ^ Anthony, T G; Fabian J R; Kimball S R; Jefferson L S (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta (NETHERLANDS) 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. ISSN 0006-3002. PMID 10858531. 
  4. ^ Kebache, Sem; Zuo Dongmei; Chevet Eric; Larose Louise (April 2002). "Modulation of protein translation by Nck-1". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5406–5411. doi:10.1073/pnas.082483399. ISSN 0027-8424. PMC 122782. PMID 11959995. 

Further reading[edit]