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Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Symbols EIF2B2 ; EIF-2Bbeta; EIF2B
External IDs OMIM606454 MGI2145118 HomoloGene6507 GeneCards: EIF2B2 Gene
RNA expression pattern
PBB GE EIF2B2 202461 at tn.png
More reference expression data
Species Human Mouse
Entrez 8892 217715
Ensembl ENSG00000119718 ENSMUSG00000004788
UniProt P49770 Q99LD9
RefSeq (mRNA) NM_014239 NM_145445
RefSeq (protein) NP_055054 NP_663420
Location (UCSC) Chr 14:
75.47 – 75.48 Mb
Chr 12:
85.22 – 85.23 Mb
PubMed search [1] [2]

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.[1][2]

Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.[supplied by OMIM][2]


EIF2B2 has been shown to interact with EIF2B5[3] and NCK1.[4]


  1. ^ Yang W, Hinnebusch AG (December 1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol Cell Biol 16 (11): 6603–16. PMC 231662. PMID 8887689. 
  2. ^ a b "Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa". 
  3. ^ Anthony, T G; Fabian J R; Kimball S R; Jefferson L S (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta (NETHERLANDS) 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. ISSN 0006-3002. PMID 10858531. 
  4. ^ Kebache, Sem; Zuo Dongmei; Chevet Eric; Larose Louise (April 2002). "Modulation of protein translation by Nck-1". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5406–5411. doi:10.1073/pnas.082483399. ISSN 0027-8424. PMC 122782. PMID 11959995. 

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