EIF2S2

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Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
Identifiers
Symbols EIF2S2 ; EIF2; EIF2B; EIF2beta; PPP1R67; eIF-2-beta
External IDs OMIM603908 MGI1914454 HomoloGene2904 GeneCards: EIF2S2 Gene
RNA expression pattern
PBB GE EIF2S2 208726 s at tn.png
PBB GE EIF2S2 208725 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8894 67204
Ensembl ENSG00000125977 ENSMUSG00000074656
UniProt P20042 Q99L45
RefSeq (mRNA) NM_003908 NM_026030
RefSeq (protein) NP_003899 NP_080306
Location (UCSC) Chr 20:
32.68 – 32.7 Mb
Chr 2:
154.87 – 154.89 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 2 subunit 2 is a protein that in humans is encoded by the EIF2S2 gene.[1][1][2]

Function[edit]

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta (this article), and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.[2]

Regulation[edit]

Both eIF2-alpha and eIF2-beta expression is regulated by the NRF1 transcription factor.[3]

See also[edit]

References[edit]

  1. ^ a b Pathak VK, Nielsen PJ, Trachsel H, Hershey JW (Sep 1988). "Structure of the beta subunit of translational initiation factor eIF-2". Cell 54 (5): 633–9. doi:10.1016/S0092-8674(88)80007-2. PMID 3044606. 
  2. ^ a b "Entrez Gene: EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa". 
  3. ^ Chiorini JA, Miyamoto S, Harkin SJ, Safer B (February 1999). "Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter". J. Biol. Chem. 274 (7): 4195–201. doi:10.1074/jbc.274.7.4195. PMID 9933616. 

Further reading[edit]