EIF2S3

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Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
Identifiers
Symbols EIF2S3 ; EIF2; EIF2G; EIF2gamma; eIF-2gA
External IDs OMIM300161 MGI1349431 HomoloGene99414 GeneCards: EIF2S3 Gene
RNA expression pattern
PBB GE EIF2S3 205321 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1968 26908
Ensembl ENSG00000130741 ENSMUSG00000069049
UniProt P41091 Q9Z0N2
RefSeq (mRNA) NM_001415 NM_012011
RefSeq (protein) NP_001406 NP_036141
Location (UCSC) Chr X:
24.07 – 24.1 Mb
Chr Y:
1.01 – 1.03 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 2 subunit 3 is a protein that in humans is encoded by the EIF2S3 gene.[1][2][3][1][2]

Function[edit]

Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma (this article), with the protein encoded by this gene representing the gamma subunit.[3]

See also[edit]

References[edit]

  1. ^ a b Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC (Mar 1994). "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit". J Biol Chem 269 (5): 3415–22. PMID 8106381. 
  2. ^ a b Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM (Dec 1998). "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution". Hum Mol Genet 7 (11): 1725–37. doi:10.1093/hmg/7.11.1725. PMID 9736774. 
  3. ^ a b "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa". 

Further reading[edit]