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Eukaryotic translation initiation factor 3, subunit B
PBB Protein EIF3S9 image.jpg
PDB rendering based on 2nlw.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF3B ; EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9; PRT1
External IDs OMIM603917 MGI106478 HomoloGene2780 GeneCards: EIF3B Gene
RNA expression pattern
PBB GE EIF3S9 211501 s at tn.png
PBB GE EIF3S9 203462 x at tn.png
PBB GE EIF3S9 208688 x at tn.png
More reference expression data
Species Human Mouse
Entrez 8662 27979
Ensembl ENSG00000106263 ENSMUSG00000056076
UniProt P55884 Q8JZQ9
RefSeq (mRNA) NM_001037283 NM_133916
RefSeq (protein) NP_001032360 NP_598677
Location (UCSC) Chr 7:
2.39 – 2.42 Mb
Chr 5:
140.42 – 140.44 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 3 subunit B is a protein that in humans is encoded by the EIF3B gene.[1][2]


EIF3B has been shown to interact with P70-S6 Kinase 1[3] and EIF3A.[1][4][5][6]


  1. ^ a b Méthot N, Rom E, Olsen H, Sonenberg N (February 1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. PMID 8995410. 
  2. ^ "Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa". 
  3. ^ Holz MK, Ballif BA, Gygi SP, Blenis J (November 2005). "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events". Cell 123 (4): 569–80. doi:10.1016/j.cell.2005.10.024. PMID 16286006. 
  4. ^ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125. 
  5. ^ Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. PMC 1440840. PMID 16541103. 
  6. ^ Block KL, Vornlocher HP, Hershey JW (November 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659. 

Further reading[edit]