EIF3B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Eukaryotic translation initiation factor 3, subunit B
PBB Protein EIF3S9 image.jpg
PDB rendering based on 2nlw.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EIF3B ; EIF3-ETA; EIF3-P110; EIF3-P116; EIF3S9; PRT1
External IDs OMIM603917 MGI106478 HomoloGene2780 GeneCards: EIF3B Gene
RNA expression pattern
PBB GE EIF3S9 211501 s at tn.png
PBB GE EIF3S9 203462 x at tn.png
PBB GE EIF3S9 208688 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8662 27979
Ensembl ENSG00000106263 ENSMUSG00000056076
UniProt P55884 Q8JZQ9
RefSeq (mRNA) NM_001037283 NM_133916
RefSeq (protein) NP_001032360 NP_598677
Location (UCSC) Chr 7:
2.39 – 2.42 Mb
Chr 5:
140.42 – 140.44 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 3 subunit B is a protein that in humans is encoded by the EIF3B gene.[1][2]


Interactions[edit]

EIF3B has been shown to interact with P70-S6 Kinase 1[3] and EIF3A.[1][4][5][6]

References[edit]

  1. ^ a b Methot N, Rom E, Olsen H, Sonenberg N (February 1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J Biol Chem 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. PMID 8995410. 
  2. ^ "Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa". 
  3. ^ Holz, Marina K; Ballif Bryan A; Gygi Steven P; Blenis John (November 2005). "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events". Cell (United States) 123 (4): 569–80. doi:10.1016/j.cell.2005.10.024. ISSN 0092-8674. PMID 16286006. 
  4. ^ Mayeur, Greg L; Fraser Christopher S; Peiretti Franck; Block Karen L; Hershey John W B (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. (Germany) 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. ISSN 0014-2956. PMID 14519125. 
  5. ^ Harris, Thurl E; Chi An; Shabanowitz Jeffrey; Hunt Donald F; Rhoads Robert E; Lawrence John C (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. (England) 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. ISSN 0261-4189. PMC 1440840. PMID 16541103. 
  6. ^ Block, K L; Vornlocher H P; Hershey J W (November 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. (UNITED STATES) 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. ISSN 0021-9258. PMID 9822659. 

Further reading[edit]