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Eukaryotic translation initiation factor 3, subunit D
Symbols EIF3D ; EIF3S7; eIF3-p66; eIF3-zeta
External IDs OMIM603915 MGI1933181 HomoloGene2782 GeneCards: EIF3D Gene
RNA expression pattern
PBB GE EIF3S7 200005 at tn.png
More reference expression data
Species Human Mouse
Entrez 8664 55944
Ensembl ENSG00000100353 ENSMUSG00000016554
UniProt O15371 O70194
RefSeq (mRNA) NM_003753 NM_018749
RefSeq (protein) NP_003744 NP_061219
Location (UCSC) Chr 22:
36.91 – 36.93 Mb
Chr 15:
77.96 – 77.97 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 3 subunit D is a protein that in humans is encoded by the EIF3D gene.[1][2]

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.[2]


EIF3D has been shown to interact with PHLDA1[3] and EIF3A.[4][5][6]


  1. ^ Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW (Nov 1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly". J Biol Chem 272 (43): 27042–52. doi:10.1074/jbc.272.43.27042. PMID 9341143. 
  2. ^ a b "Entrez Gene: EIF3S7 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa". 
  3. ^ Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. (England) 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN 0898-6568. PMID 11369516. 
  4. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ Mayeur, Greg L; Fraser Christopher S; Peiretti Franck; Block Karen L; Hershey John W B (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. (Germany) 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. ISSN 0014-2956. PMID 14519125. 
  6. ^ Block, K L; Vornlocher H P; Hershey J W (Nov 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. (UNITED STATES) 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. ISSN 0021-9258. PMID 9822659. 

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