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Eukaryotic translation initiation factor 3, subunit F
Symbols EIF3F ; EIF3S5; eIF3-p47
External IDs OMIM603914 MGI1913335 HomoloGene2783 GeneCards: EIF3F Gene
EC number
Species Human Mouse
Entrez 8665 66085
Ensembl ENSG00000175390 ENSMUSG00000031029
UniProt O00303 Q9DCH4
RefSeq (mRNA) NM_003754 NM_025344
RefSeq (protein) NP_003745 NP_079620
Location (UCSC) Chr 11:
7.99 – 8.02 Mb
Chr 7:
108.93 – 108.94 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 3 subunit F is a protein that in humans is encoded by the EIF3F gene.[1][2]


EIF3F has been shown to interact with Mammalian target of rapamycin[3] and EIF3A.[4][5][6]


  1. ^ Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW (Nov 1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly". J. Biol. Chem. 272 (43): 27042–52. doi:10.1074/jbc.272.43.27042. PMID 9341143. 
  2. ^ "Entrez Gene: EIF3S5 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa". 
  3. ^ Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (Apr 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. PMC 1440840. PMID 16541103. 
  4. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125. 
  6. ^ Block KL, Vornlocher HP, Hershey JW (Nov 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659. 

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