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Eukaryotic translation initiation factor 3, subunit I
Symbols EIF3I ; EIF3S2; PRO2242; TRIP-1; TRIP1; eIF3-beta; eIF3-p36
External IDs OMIM603911 MGI1860763 HomoloGene2786 GeneCards: EIF3I Gene
RNA expression pattern
PBB GE EIF3S2 208756 at tn.png
More reference expression data
Species Human Mouse
Entrez 8668 54709
Ensembl ENSG00000084623 ENSMUSG00000028798
UniProt Q13347 Q9QZD9
RefSeq (mRNA) NM_003757 NM_018799
RefSeq (protein) NP_003748 NP_061269
Location (UCSC) Chr 1:
32.69 – 32.7 Mb
Chr 4:
129.59 – 129.6 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 3 subunit I is a protein that in humans is encoded by the EIF3I gene.[1][2][3]


EIF3I has been shown to interact with TGF beta 1[4] and EIF3A.[2][5][6]


  1. ^ Chen RH, Miettinen PJ, Maruoka EM, Choy L, Derynck R (Nov 1995). "A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor". Nature 377 (6549): 548–52. doi:10.1038/377548a0. PMID 7566156. 
  2. ^ a b Asano K, Kinzy TG, Merrick WC, Hershey JW (Feb 1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". J. Biol. Chem. 272 (2): 1101–9. doi:10.1074/jbc.272.2.1101. PMID 8995409. 
  3. ^ "Entrez Gene: EIF3S2 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa". 
  4. ^ Choy L, Derynck R (Nov 1998). "The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response". J. Biol. Chem. 273 (47): 31455–62. doi:10.1074/jbc.273.47.31455. PMID 9813058. 
  5. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125. 

Further reading[edit]