From Wikipedia, the free encyclopedia
Jump to: navigation, search
Eukaryotic translation initiation factor 4E family member 2
Protein EIF4E2 PDB 2jgb.png
PDB rendering based on 2jgb.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF4E2 ; 4E-LP; 4EHP; EIF4EL3; IF4e
External IDs OMIM605895 MGI1914440 HomoloGene128466 GeneCards: EIF4E2 Gene
RNA expression pattern
PBB GE EIF4E2 213571 s at tn.png
PBB GE EIF4E2 209393 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9470 26987
Ensembl ENSG00000135930 ENSMUSG00000026254
UniProt O60573 Q8BMB3
RefSeq (mRNA) NM_001276336 NM_001039169
RefSeq (protein) NP_001263265 NP_001034258
Location (UCSC) Chr 2:
233.41 – 233.45 Mb
Chr 1:
87.21 – 87.24 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.[1][2][3] It belongs to the eukaryotic translation initiation factor 4E family.


EIF4E2 has been shown to interact with ARIH1.[4]


  1. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160. 
  2. ^ Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK, Sonenberg N (Jun 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". J Biol Chem 273 (21): 13104–9. doi:10.1074/jbc.273.21.13104. PMID 9582349. 
  3. ^ "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2". 
  4. ^ Tan, Nancy G S; Ardley Helen C; Scott Gina B; Rose Stephen A; Markham Alexander F; Robinson Philip A (Nov 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. (Netherlands) 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. ISSN 0014-5793. PMID 14623119. 

Further reading[edit]