EIF4G3

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Eukaryotic translation initiation factor 4 gamma, 3
Protein EIF4G3 PDB 1hu3.png
PDB rendering based on 1hu3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EIF4G3 ; eIF-4G 3; eIF4G 3; eIF4GII
External IDs OMIM603929 MGI1923935 HomoloGene2789 GeneCards: EIF4G3 Gene
RNA expression pattern
PBB GE EIF4G3 201935 s at tn.png
PBB GE EIF4G3 201936 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8672 230861
Ensembl ENSG00000075151 ENSMUSG00000028760
UniProt O43432 Q80XI3
RefSeq (mRNA) NM_001198801 NM_001256195
RefSeq (protein) NP_001185730 NP_001243124
Location (UCSC) Chr 1:
21.13 – 21.5 Mb
Chr 4:
137.99 – 138.21 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene.[1][2] The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template.[3] Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.[4]


Interactions[edit]

EIF4G3 has been shown to interact with PABPC1.[5]

References[edit]

  1. ^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol Cell Biol 18 (1): 334–42. PMC 121501. PMID 9418880. 
  2. ^ "Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3". 
  3. ^ Gingras AC, Raught B, Sonenberg N (2000). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469. 
  4. ^ Gradi A, Imataka H, Svitkin YV, et al. (1998). "A novel functional human eukaryotic translation initiation factor 4G.". Mol. Cell. Biol. 18 (1): 334–42. PMC 121501. PMID 9418880. 
  5. ^ Imataka, H; Gradi A; Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. (ENGLAND) 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. ISSN 0261-4189. PMC 1171091. PMID 9857202. 

Further reading[edit]