EIF4H

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Eukaryotic translation initiation factor 4H
Protein EIF4H PDB 2dng.png
PDB rendering based on 2dng.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EIF4H ; WBSCR1; WSCR1; eIF-4H
External IDs OMIM603431 MGI1341822 HomoloGene32536 ChEMBL: 1293274 GeneCards: EIF4H Gene
Orthologs
Species Human Mouse
Entrez 7458 22384
Ensembl ENSG00000106682 ENSMUSG00000040731
UniProt Q15056 Q9WUK2
RefSeq (mRNA) NM_022170 NM_033561
RefSeq (protein) NP_071496 NP_291039
Location (UCSC) Chr 7:
73.59 – 73.61 Mb
Chr 5:
134.62 – 134.64 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.[1][2][3]

This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization.

This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.[3]

EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity.[4]

References[edit]

  1. ^ Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC (Apr 1998). "Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H". J Biol Chem 273 (13): 7579–87. doi:10.1074/jbc.273.13.7579. PMID 9516461. 
  2. ^ Doepker RC, Hsu WL, Saffran HA, Smiley JR (Apr 2004). "Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H". J Virol 78 (9): 4684–99. doi:10.1128/JVI.78.9.4684-4699.2004. PMC 387725. PMID 15078951. 
  3. ^ a b "Entrez Gene: EIF4H eukaryotic translation initiation factor 4H". 
  4. ^ "Early discovery may aid search for anti-aging drugs". 2010. 

Further reading[edit]