EIF5B

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Eukaryotic translation initiation factor 5B
Identifiers
Symbols EIF5B ; IF2
External IDs OMIM606086 MGI2441772 HomoloGene134613 GeneCards: EIF5B Gene
RNA expression pattern
PBB GE EIF5B 201024 x at tn.png
PBB GE EIF5B 201025 at tn.png
PBB GE EIF5B 201027 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9669 226982
Ensembl ENSG00000158417 ENSMUSG00000026083
UniProt O60841 Q05D44
RefSeq (mRNA) NM_015904 NM_198303
RefSeq (protein) NP_056988 NP_938045
Location (UCSC) Chr 2:
99.95 – 100.02 Mb
Chr 1:
38 – 38.06 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.[1][2][3]

Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.[3]

References[edit]

  1. ^ Lee JH, Choi SK, Roll-Mecak A, Burley SK, Dever TE (May 1999). "Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2". Proc Natl Acad Sci U S A 96 (8): 4342–7. doi:10.1073/pnas.96.8.4342. PMC 16334. PMID 10200264. 
  2. ^ Wilson SA, Sieiro-Vazquez C, Edwards NJ, Iourin O, Byles ED, Kotsopoulou E, Adamson CS, Kingsman SM, Kingsman AJ, Martin-Rendon E (Oct 1999). "Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix". Biochem J. 342. ( Pt 1): 97–103. PMC 1220441. PMID 10432305. 
  3. ^ a b "Entrez Gene: EIF5B eukaryotic translation initiation factor 5B". 

Further reading[edit]