ELAVL1

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ELAV like RNA binding protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ELAVL1 ; ELAV1; HUR; Hua; MelG
External IDs OMIM603466 MGI1100851 HomoloGene20367 ChEMBL: 1250379 GeneCards: ELAVL1 Gene
RNA expression pattern
PBB GE ELAVL1 201726 at tn.png
PBB GE ELAVL1 201727 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1994 15568
Ensembl ENSG00000066044 ENSMUSG00000040028
UniProt Q15717 P70372
RefSeq (mRNA) NM_001419 NM_010485
RefSeq (protein) NP_001410 NP_034615
Location (UCSC) Chr 19:
8.02 – 8.07 Mb
Chr 8:
4.28 – 4.33 Mb
PubMed search [1] [2]

ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene.[1][2]

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It stabilizes mRNAs and thereby regulates gene expression.[3]

A consensus secondary structure and primary sequence for the targets of the HuR RNA binding protein.[4][5]

See also[edit]

References[edit]

  1. ^ Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H (Jun 1996). "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein". J Biol Chem 271 (14): 8144–8151. doi:10.1074/jbc.271.14.8144. PMID 8626503. 
  2. ^ Ma WJ, Furneaux H (Feb 1997). "Localization of the human HuR gene to chromosome 19p13.2". Hum Genet 99 (1): 32–33. doi:10.1007/s004390050305. PMID 9003489. 
  3. ^ "Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)". 
  4. ^ López de Silanes, I; Zhan, M; Lal, A; Yang, X; Gorospe, M (Mar 2, 2004). "Identification of a target RNA motif for RNA-binding protein HuR.". Proceedings of the National Academy of Sciences of the United States of America 101 (9): 2987–92. doi:10.1073/pnas.0306453101. PMID 14981256. 
  5. ^ Dassi, E; Zuccotti, P; Leo, S; Provenzani, A; Assfalg, M; D'Onofrio, M; Riva, P; Quattrone, A (Mar 1, 2013). "Hyper conserved elements in vertebrate mRNA 3'-UTRs reveal a translational network of RNA-binding proteins controlled by HuR.". Nucleic acids research 41 (5): 3201–16. doi:10.1093/nar/gkt017. PMID 23376935. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.