HuD (protein)

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ELAV like neuron-specific RNA binding protein 4
PBB Protein ELAVL4 image.jpg
PDB rendering based on 1fxl.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ELAVL4 ; HUD; PNEM
External IDs OMIM168360 MGI107427 HomoloGene40729 GeneCards: ELAVL4 Gene
RNA expression pattern
PBB GE ELAVL4 206051 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1996 15572
Ensembl ENSG00000162374 ENSMUSG00000028546
UniProt P26378 Q61701
RefSeq (mRNA) NM_001144774 NM_001038698
RefSeq (protein) NP_001138246 NP_001033787
Location (UCSC) Chr 1:
50.51 – 50.67 Mb
Chr 4:
110.2 – 110.35 Mb
PubMed search [1] [2]

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.[1][2]

The HuD/ELAVL4 protein is an RNA-binding protein.[3]

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[4][5]

Interactions[edit]

HuD (protein) has been shown to interact with NXF1.[6]

References[edit]

  1. ^ Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755. 
  2. ^ "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)". 
  3. ^ Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.". Cell 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278. 
  4. ^ Nora Perrone-Bizzozero and Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657. 
  5. ^ Federico Bolognani and Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436. 
  6. ^ Saito, Kuniaki; Fujiwara Toshinobu; Katahira Jun; Inoue Kunio; Sakamoto Hiroshi (Aug 2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. (United States) 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. ISSN 0006-291X. PMID 15358174. 

Further reading[edit]