HuD (protein)

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ELAV like neuron-specific RNA binding protein 4
PBB Protein ELAVL4 image.jpg
PDB rendering based on 1fxl.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ELAVL4 ; HUD; PNEM
External IDs OMIM168360 MGI107427 HomoloGene40729 GeneCards: ELAVL4 Gene
RNA expression pattern
PBB GE ELAVL4 206051 at tn.png
More reference expression data
Species Human Mouse
Entrez 1996 15572
Ensembl ENSG00000162374 ENSMUSG00000028546
UniProt P26378 Q61701
RefSeq (mRNA) NM_001144774 NM_001038698
RefSeq (protein) NP_001138246 NP_001033787
Location (UCSC) Chr 1:
50.51 – 50.67 Mb
Chr 4:
110.2 – 110.35 Mb
PubMed search [1] [2]

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.[1][2]

The HuD/ELAVL4 protein is an RNA-binding protein.[3]

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[4][5]


HuD (protein) has been shown to interact with NXF1.[6]


  1. ^ Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755. 
  2. ^ "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)". 
  3. ^ Szabo A, Dalmau J, Manley G et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.". Cell 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278. 
  4. ^ Nora Perrone-Bizzozero and Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657. 
  5. ^ Federico Bolognani and Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436. 
  6. ^ Saito, Kuniaki; Fujiwara Toshinobu; Katahira Jun; Inoue Kunio; Sakamoto Hiroshi (Aug 2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. (United States) 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. ISSN 0006-291X. PMID 15358174. 

Further reading[edit]