E74-like factor 5 (ets domain transcription factor), is a gene found in both mice and humans. In humans it is also called ESE2.
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Zhou J, Ng AY, Tymms MJ, et al. (1998). "A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines". Oncogene17 (21): 2719–32. doi:10.1038/sj.onc.1202198. PMID9840936.
Oettgen P, Kas K, Dube A, et al. (1999). "Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes". J. Biol. Chem.274 (41): 29439–52. doi:10.1074/jbc.274.41.29439. PMID10506207.
Lapinskas EJ, Palmer J, Ricardo S, et al. (2005). "A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands". Histochem. Cell Biol.122 (6): 521–6. doi:10.1007/s00418-004-0713-x. PMID15655699.
Yaniw D, Hu J (2005). "Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1". Cell Res.15 (6): 423–9. doi:10.1038/sj.cr.7290310. PMID15987600.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Tummala R, Sinha S (2006). "Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor". J. Cell. Biochem.97 (4): 766–81. doi:10.1002/jcb.20685. PMID16229011.
Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature440 (7083): 497–500. doi:10.1038/nature04632. PMID16554811.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID16713569.