EMCN

EMCN
Identifiers
Aliases	EMCN, EMCN2, MUC14, endomucin
External IDs	OMIM: 608350 MGI: 1891716 HomoloGene: 9438 GeneCards: EMCN
Gene location (Human)
Chr.	Chromosome 4 (human)
End	100,880,126 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	137,137,946 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; lower lobe of lung; ; parietal pleura; ; renal medulla; ; right lobe of thyroid gland; ; visceral pleura; ; kidney; ; right lung; ; gallbladder; ; left lobe of thyroid gland;
	Top expressed in
	left lung lobe; ; adrenal gland; ; atrioventricular valve; ; atrium; ; interventricular septum; ; right lung; ; kidney; ; right lung lobe; ; body of femur; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Orthologs
	51705
	59308
	ENSG00000164035
	ENSMUSG00000054690
	Q9ULC0
	Q9R0H2
	NM_001159694; NM_016242
	NM_001163522; NM_016885
	NP_001153166; NP_057326
	NP_001156994; NP_058581
	Wikidata
View/Edit Human	View/Edit Mouse

Endomucin is a protein that in humans is encoded by the EMCN gene.^[5]^[6]^[7] Endomucin is a marker for endothelial cells^[8] and hematopoietic stem cells.^[9]

Function[edit]

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.^[5]^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164035 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054690 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.
^ Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
^ ^a ^b "Entrez Gene: EMCN endomucin".
^ Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288 (1): 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.
^ Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.

Further reading[edit]

Li G, Miles A, Line A, Rees RC (March 2004). "Identification of tumour antigens by serological analysis of cDNA expression cloning". Cancer Immunology, Immunotherapy. 53 (3): 139–43. doi:10.1007/s00262-003-0471-y. PMID 14722670. S2CID 10785466.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D (May 2002). "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope". The American Journal of Pathology. 160 (5): 1669–81. doi:10.1016/S0002-9440(10)61114-5. PMC 1850881. PMID 12000719.
Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (June 2002). "Serological identification and expression analysis of gastric cancer-associated genes". British Journal of Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D (December 2002). "Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin". The Journal of Investigative Dermatology. 119 (6): 1388–93. doi:10.1046/j.1523-1747.2002.19647.x. PMID 12485444.
Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M (September 2004). "Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling". International Immunology. 16 (9): 1265–74. doi:10.1093/intimm/dxh128. PMID 15249540.
Reckzeh K.; Kizilkaya H.; Søgaard Helbo A.; Estruch Alrich M.; et al. (2018). "Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin". Blood Advances. 2 (13): 1628–1632. doi:10.1182/bloodadvances.2018015743. PMC 6039657. PMID 29986855.</ref>

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164035 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054690 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Kinoshita_2001-5] Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125. S2CID 23615506.

[pmid11594763-6] Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.

[entrez-7] "Entrez Gene: EMCN endomucin".

[8] Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288 (1): 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.

[9] Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.

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