ENTPD1

Ectonucleoside triphosphate diphosphohydrolase 1
Identifiers
Symbols	ENTPD1; ATPDase; CD39; DKFZp686D194; DKFZp686I093; FLJ40921; FLJ40959; NTPDase-1
External IDs	OMIM: 601752 MGI: 102805 HomoloGene: 20423 GeneCards: ENTPD1 Gene
EC number	3.6.1.5
Gene Ontology Molecular function • nucleotide binding • ATP binding • hydrolase activity • nucleoside-diphosphatase activity • nucleoside-triphosphatase activity Cellular component • basal lamina • plasma membrane • integral to plasma membrane Biological process • ATP catabolic process • cell adhesion • G-protein coupled receptor protein signaling pathway • blood coagulation • purine ribonucleoside diphosphate catabolic process • platelet activation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	953	12495
Ensembl	ENSG00000138185	ENSMUSG00000048120
UniProt	P49961	Q544U5
RefSeq (mRNA)	NM_001098175.1	NM_009848.3
RefSeq (protein)	NP_001091645.1	NP_033978.1
Location (UCSC)	Chr 10: 97.45 – 97.64 Mb	Chr 19: 40.69 – 40.82 Mb
PubMed search	[1]	[2]

Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) also known as CD39 (Cluster of Differentiation 39), is a human gene.

See also

• Cluster of differentiation

Further reading

• Maliszewski CR, Delespesse GJ, Schoenborn MA et al (1994). "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization". J. Immunol. 153 (8): 3574–83. PMID 7930580. 
• Christoforidis S, Papamarcaki T, Galaris D et al (1996). "Purification and properties of human placental ATP diphosphohydrolase". Eur. J. Biochem. 234 (1): 66–74. doi:10.1111/j.1432-1033.1995.066_c.x. PMID 8529670. 
• Wang TF, Guidotti G (1996). "CD39 is an ecto-(Ca2+,Mg2+)-apyrase". J. Biol. Chem. 271 (17): 9898–901. doi:10.1074/jbc.271.17.9898. PMID 8626624. 
• Kaczmarek E, Koziak K, Sévigny J et al (1997). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". J. Biol. Chem. 271 (51): 33116–22. doi:10.1074/jbc.271.51.33116. PMID 8955160. 
• Robson SC, Kaczmarek E, Siegel JB et al (1997). "Loss of ATP Diphosphohydrolase Activity with Endothelial Cell Activation". J. Exp. Med. 185 (1): 153–63. doi:10.1084/jem.185.1.153. PMC 2196106. PMID 8996251. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196106. 
• Gray IC, Fallowfield J, Ford S et al (1997). "An integrated physical and genetic map spanning chromosome band 10q24". Genomics 43 (1): 85–8. doi:10.1006/geno.1997.4809. PMID 9226376. 
• Makita K, Shimoyama T, Sakurai Y et al (1999). "Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation". Int. J. Hematol. 68 (3): 297–310. doi:10.1016/S0925-5710(98)00080-2. PMID 9846014. 
• Matsumoto M, Sakurai Y, Kokubo T et al (1999). "The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II". FEBS Lett. 453 (3): 335–40. doi:10.1016/S0014-5793(99)00751-6. PMID 10405171. 
• Kittel A, Kaczmarek E, Sevigny J et al (1999). "CD39 as a caveolar-associated ectonucleotidase". Biochem. Biophys. Res. Commun. 262 (3): 596–9. doi:10.1006/bbrc.1999.1254. PMID 10471369. 
• Koziak K, Kaczmarek E, Kittel A et al (2000). "Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae". J. Biol. Chem. 275 (3): 2057–62. doi:10.1074/jbc.275.3.2057. PMID 10636909. 
• Dias Neto E, Correa RG, Verjovski-Almeida S et al (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16267. 
• Goepfert C, Imai M, Brouard S et al (2001). "CD39 modulates endothelial cell activation and apoptosis". Mol. Med. 6 (7): 591–603. PMC 1949966. PMID 10997340. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1949966. 
• Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim. Biophys. Acta 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484. 
• Kittel A, Garrido M, Varga G (2002). "Localization of NTPDase1/CD39 in normal and transformed human pancreas". J. Histochem. Cytochem. 50 (4): 549–56. doi:10.1177/002215540205000412. PMID 11897808. 
• Kaneider NC, Egger P, Dunzendorfer S et al (2002). "Reversal of thrombin-induced deactivation of CD39/ATPDase in endothelial cells by HMG-CoA reductase inhibition: effects on Rho-GTPase and adenosine nucleotide metabolism". Arterioscler. Thromb. Vasc. Biol. 22 (6): 894–900. doi:10.1161/01.ATV.0000018305.95943.F7. PMID 12067895. 
• Drosopoulos JH (2002). "Roles of Asp54 and Asp213 in Ca2+ utilization by soluble human CD39/ecto-nucleotidase". Arch. Biochem. Biophys. 406 (1): 85–95. doi:10.1016/S0003-9861(02)00414-9. PMID 12234494. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Krötz F, Sohn HY, Keller M et al (2002). "Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase". Arterioscler. Thromb. Vasc. Biol. 22 (12): 2003–9. doi:10.1161/01.ATV.0000043454.08172.51. PMID 12482826. 
• Rossatto ER, da Silva LB, Pereira GS et al (2003). "ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease". Platelets 14 (1): 47–52. doi:10.1080/0953710021000062923. PMID 12623446. 
• Sørensen CE, Amstrup J, Rasmussen HN et al (2004). "Rat pancreas secretes particulate ecto-nucleotidase CD39". J. Physiol. (Lond.) 551 (Pt 3): 881–92. doi:10.1113/jphysiol.2003.049411. PMC 2343304. PMID 12832497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2343304. 

External links

• MeSH ENTPD1+protein,+human