EP4 receptor

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Prostaglandin E receptor 4 (subtype EP4)
Symbols PTGER4 ; EP4; EP4R
External IDs OMIM601586 MGI104311 HomoloGene20261 IUPHAR: 343 ChEMBL: 1836 GeneCards: PTGER4 Gene
Species Human Mouse
Entrez 5734 19219
Ensembl ENSG00000171522 ENSMUSG00000039942
UniProt P35408 P32240
RefSeq (mRNA) NM_000958 NM_001136079
RefSeq (protein) NP_000949 NP_001129551
Location (UCSC) Chr 5:
40.68 – 40.69 Mb
Chr 15:
5.21 – 5.24 Mb
PubMed search [1] [2]

Prostaglandin E receptor 4 (EP4) is a prostaglandin receptor encoded by the PTGER4 gene in humans.

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.[1]

See also[edit]


External links[edit]

  • "Prostanoid Receptors: EP4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.