EPH receptor A3

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EPH receptor A3
Protein EPHA3 PDB 2gsf.png
PDB rendering based on 2gsf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EPHA3 ; EK4; ETK; ETK1; HEK; HEK4; TYRO4
External IDs OMIM179611 MGI99612 HomoloGene21083 ChEMBL: 4954 GeneCards: EPHA3 Gene
EC number
RNA expression pattern
PBB GE EPHA3 206070 s at tn.png
PBB GE EPHA3 206071 s at tn.png
PBB GE EPHA3 gnf1h09694 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2042 13837
Ensembl ENSG00000044524 ENSMUSG00000052504
UniProt P29320 P29319
RefSeq (mRNA) NM_005233 NM_010140
RefSeq (protein) NP_005224 NP_034270
Location (UCSC) Chr 3:
89.16 – 89.53 Mb
Chr 16:
63.54 – 63.86 Mb
PubMed search [1] [2]

EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene.[1][2][3]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.[3]


EPH receptor A3 has been shown to interact with EFNB2[4][5] and EFNA5.[5][6]


  1. ^ Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A, Welch K, Loudovaris M, Rockman S, Busmanis I (March 1992). "Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line". J Biol Chem 267 (5): 3262–7. PMID 1737782. 
  2. ^ Wicks IP, Wilkinson D, Salvaris E, Boyd AW (April 1992). "Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines". Proc Natl Acad Sci U S A 89 (5): 1611–5. doi:10.1073/pnas.89.5.1611. PMC 48502. PMID 1311845. 
  3. ^ a b "Entrez Gene: EPHA3 EPH receptor A3". 
  4. ^ Cerretti, D P; Vanden Bos T; Nelson N; Kozlosky C J; Reddy P; Maraskovsky E; Park L S; Lyman S D; Copeland N G; Gilbert D J (November 1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases". Mol. Immunol. (ENGLAND) 32 (16): 1197–205. doi:10.1016/0161-5890(95)00108-5. ISSN 0161-5890. PMID 8559144. 
  5. ^ a b Lackmann, M; Mann R J, Kravets L, Smith F M, Bucci T A, Maxwell K F, Howlett G J, Olsson J E, Vanden Bos T, Cerretti D P, Boyd A W (June 1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor". J. Biol. Chem. (UNITED STATES) 272 (26): 16521–30. doi:10.1074/jbc.272.26.16521. ISSN 0021-9258. PMID 9195962. 
  6. ^ Kozlosky, C J; VandenBos T; Park L; Cerretti D P; Carpenter M K (August 1997). "LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain". Cytokine (UNITED STATES) 9 (8): 540–9. doi:10.1006/cyto.1997.0199. ISSN 1043-4666. PMID 9245480. 

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