EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5gene.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
^Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID7528718.
Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands.". Cell Tissue Res.290 (2): 251–9. doi:10.1007/s004410050929. PMID9321686.
Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1.". Cell Tissue Res.290 (2): 261–4. doi:10.1007/s004410050930. PMID9321687.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci.2 (3): 155–64. doi:10.1038/35058515. PMID11256076.
Fox GM, Holst PL, Chute HT et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.". Oncogene10 (5): 897–905. PMID7898931.
Davis S, Gale NW, Aldrich TH et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.". Science266 (5186): 816–9. doi:10.1126/science.7973638. PMID7973638.
Gale NW, Holland SJ, Valenzuela DM et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.". Neuron17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID8755474.
Miescher GC, Taylor V, Olivieri G et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.". Brain Res. Mol. Brain Res.46 (1-2): 17–24. doi:10.1016/S0169-328X(96)00268-9. PMID9191074.
Stein E, Savaskan NE, Ninnemann O et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting.". J. Neurosci.19 (20): 8885–93. PMID10516308.