EPHA7

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EPH receptor A7
Protein EPHA7 PDB 2REI.png
Rendering based on PDB 2REI.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EPHA7 ; EHK3; HEK11
External IDs OMIM602190 MGI95276 HomoloGene20935 ChEMBL: 4602 GeneCards: EPHA7 Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE EPHA7 206852 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2045 13841
Ensembl ENSG00000135333 ENSMUSG00000028289
UniProt Q15375 Q61772
RefSeq (mRNA) NM_004440 NM_001122889
RefSeq (protein) NP_004431 NP_001116361
Location (UCSC) Chr 6:
93.95 – 94.13 Mb
Chr 4:
28.81 – 28.97 Mb
PubMed search [1] [2]

Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene.[1][2]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[2]

References[edit]

  1. ^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
  2. ^ a b "Entrez Gene: EPHA7 EPH receptor A7". 

Further reading[edit]