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EPH receptor A8
Protein EPHA8 PDB 1ucv.png
PDB rendering based on 1ucv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EPHA8 ; EEK; EK3; HEK3
External IDs OMIM176945 MGI109378 HomoloGene22436 ChEMBL: 4134 GeneCards: EPHA8 Gene
EC number
Species Human Mouse
Entrez 2046 13842
Ensembl ENSG00000070886 ENSMUSG00000028661
UniProt P29322 O09127
RefSeq (mRNA) NM_001006943 NM_007939
RefSeq (protein) NP_001006944 NP_031965
Location (UCSC) Chr 1:
22.89 – 22.93 Mb
Chr 4:
136.93 – 136.96 Mb
PubMed search [1] [2]

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.[1][2]


This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.[2]


EPHA8 has been shown to interact with FYN.[3]


  1. ^ Chan J, Watt VM (Aug 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene 6 (6): 1057–61. PMID 1648701. 
  2. ^ a b "Entrez Gene: EPHA8 EPH receptor A8". 
  3. ^ Choi S, Park S (Sep 1999). "Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity". Oncogene 18 (39): 5413–22. doi:10.1038/sj.onc.1202917. PMID 10498895. 

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