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EPH receptor B3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EPHB3 ; ETK2; HEK2; TYRO6
External IDs OMIM601839 MGI104770 HomoloGene20938 IUPHAR: 1832 ChEMBL: 4901 GeneCards: EPHB3 Gene
EC number
RNA expression pattern
PBB GE EPHB3 1438 at tn.png
PBB GE EPHB3 204600 at tn.png
More reference expression data
Species Human Mouse
Entrez 2049 13845
Ensembl ENSG00000182580 ENSMUSG00000005958
UniProt P54753 P54754
RefSeq (mRNA) NM_004443 NM_010143
RefSeq (protein) NP_004434 NP_034273
Location (UCSC) Chr 3:
184.28 – 184.3 Mb
Chr 16:
21.2 – 21.22 Mb
PubMed search [1] [2]

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.[1][2]


Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[2]


EPHB3 has been shown to interact with MLLT4[3] and RAS p21 protein activator 1.[4]


  1. ^ Böhme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K et al. (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene 8 (10): 2857–62. PMID 8397371. 
  2. ^ a b "Entrez Gene: EPHB3 EPH receptor B3". 
  3. ^ Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U et al. (Aug 1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552. 
  4. ^ Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711. 

Further reading[edit]