Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3gene.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
^Bohme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rubsamen-Waigmann H (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene8 (10): 2857–62. PMID8397371.
^Hock, B; Böhme B; Karn T; Feller S; Rübsamen-Waigmann H; Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene (ENGLAND) 17 (2): 255–60. doi:10.1038/sj.onc.1201907. ISSN0950-9232. PMID9674711.
Bergemann AD, Zhang L, Chiang MK, et al. (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube.". Oncogene16 (4): 471–80. doi:10.1038/sj.onc.1201557. PMID9484836.
Hock B, Böhme B, Karn T, et al. (1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.". Oncogene17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID9674711.
Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.". Eur. J. Neurosci.10 (5): 1574–80. doi:10.1046/j.1460-9568.1998.00180.x. PMID9751130.