EPH receptor B4

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EPH receptor B4
Protein EPHB4 PDB 2bba.png
PDB rendering based on 2bba.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EPHB4 ; HTK; MYK1; TYRO11
External IDs OMIM600011 MGI104757 HomoloGene20939 IUPHAR: 1833 ChEMBL: 5147 GeneCards: EPHB4 Gene
EC number
RNA expression pattern
PBB GE EPHB4 202894 at tn.png
PBB GE EPHB4 216680 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2050 13846
Ensembl ENSG00000196411 ENSMUSG00000029710
UniProt P54760 P54761
RefSeq (mRNA) NM_004444 NM_001159571
RefSeq (protein) NP_004435 NP_001153043
Location (UCSC) Chr 7:
100.4 – 100.43 Mb
Chr 5:
137.35 – 137.38 Mb
PubMed search [1] [2]

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.[1][2]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.[2][3]


  1. ^ Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily". J Biol Chem 269 (19): 14211–8. PMID 8188704. 
  2. ^ a b "Entrez Gene: EPHB4 EPH receptor B4". 
  3. ^ Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999). "Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.". Mol. Cell 4 (3): 403–14. doi:10.1016/S1097-2765(00)80342-1. PMID 10518221. 

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