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EPH receptor B6
Symbols EPHB6 ; HEP
External IDs OMIM602757 MGI1096338 HomoloGene20940 ChEMBL: 5836 GeneCards: EPHB6 Gene
EC number
RNA expression pattern
PBB GE EPHB6 204718 at tn.png
More reference expression data
Species Human Mouse
Entrez 2051 13848
Ensembl ENSG00000106123 ENSMUSG00000029869
UniProt O15197 O08644
RefSeq (mRNA) NM_001280794 NM_001146351
RefSeq (protein) NP_001267723 NP_001139823
Location (UCSC) Chr 7:
142.55 – 142.57 Mb
Chr 6:
41.61 – 41.62 Mb
PubMed search [1] [2]

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.[1]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.[1]


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