EPH receptor A1

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EPH receptor A1
Protein EPHA1 PDB 1x5a.png
PDB rendering based on 1x5a.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EPHA1 ; EPH; EPHT; EPHT1
External IDs OMIM179610 MGI107381 HomoloGene3835 ChEMBL: 5810 GeneCards: EPHA1 Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE EPHA1 205977 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2041 13835
Ensembl ENSG00000146904 ENSMUSG00000029859
UniProt P21709 Q60750
RefSeq (mRNA) NM_005232 NM_023580
RefSeq (protein) NP_005223 NP_076069
Location (UCSC) Chr 7:
143.09 – 143.11 Mb
Chr 6:
42.36 – 42.37 Mb
PubMed search [1] [2]

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.[1][2]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.[2]

References[edit]

  1. ^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
  2. ^ a b "Entrez Gene: EPHA1 EPH receptor A1". 

Further reading[edit]