EPH receptor B1

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EPH receptor B1
Protein EPHB1 PDB 2djs.png
PDB rendering based on 2djs.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EPHB1 ; ELK; EPHT2; Hek6; NET
External IDs OMIM600600 MGI1096337 HomoloGene20936 ChEMBL: 5072 GeneCards: EPHB1 Gene
EC number
Species Human Mouse
Entrez 2047 270190
Ensembl ENSG00000154928 ENSMUSG00000032537
UniProt P54762 Q8CBF3
RefSeq (mRNA) NM_004441 NM_001168296
RefSeq (protein) NP_004432 NP_001161768
Location (UCSC) Chr 3:
134.32 – 134.98 Mb
Chr 9:
101.92 – 102.35 Mb
PubMed search [1] [2]

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.[1][2]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[2]


EPH receptor B1 has been shown to interact with GRB7,[3] ACP1[4] and NCK1.[5]


  1. ^ Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N (Aug 1996). "cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain". Genomics 29 (2): 426–37. doi:10.1006/geno.1995.9985. PMID 8666391. 
  2. ^ a b "Entrez Gene: EPHB1 EPH receptor B1". 
  3. ^ Han, Dong Cho; Shen Tang-Long; Miao Hui; Wang Bingcheng; Guan Jun-Lin (Nov 2002). "EphB1 associates with Grb7 and regulates cell migration". J. Biol. Chem. (United States) 277 (47): 45655–61. doi:10.1074/jbc.M203165200. ISSN 0021-9258. PMID 12223469. 
  4. ^ Stein, E; Lane A A; Cerretti D P; Schoecklmann H O; Schroff A D; Van Etten R L; Daniel T O (Mar 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes Dev. (UNITED STATES) 12 (5): 667–78. doi:10.1101/gad.12.5.667. ISSN 0890-9369. PMC 316584. PMID 9499402. 
  5. ^ Stein, E; Huynh-Do U; Lane A A; Cerretti D P; Daniel T O (Jan 1998). "Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase". J. Biol. Chem. (UNITED STATES) 273 (3): 1303–8. doi:10.1074/jbc.273.3.1303. ISSN 0021-9258. PMID 9430661. 

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