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Epsin 2
Symbols EPN2 ; EHB21
External IDs OMIM607263 MGI1333766 HomoloGene40710 GeneCards: EPN2 Gene
RNA expression pattern
PBB GE EPN2 203463 s at tn.png
PBB GE EPN2 203464 s at tn.png
More reference expression data
Species Human Mouse
Entrez 22905 13855
Ensembl ENSG00000072134 ENSMUSG00000001036
UniProt O95208 Q8CHU3
RefSeq (mRNA) NM_001102664 NM_001252188
RefSeq (protein) NP_001096134 NP_001239117
Location (UCSC) Chr 17:
19.12 – 19.24 Mb
Chr 11:
61.52 – 61.58 Mb
PubMed search [1] [2]

Epsin-2 is a protein that in humans is encoded by the EPN2 gene.[1][2]

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[2]


  1. ^ Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P (Dec 1999). "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module". J Biol Chem 274 (48): 33959–65. doi:10.1074/jbc.274.48.33959. PMID 10567358. 
  2. ^ a b "Entrez Gene: EPN2 epsin 2". 

Further reading[edit]