ERAF

Alpha hemoglobin stabilizing protein
	; PDB rendering based on 1w09.
Available structures
PDB	1W09, 1W0A, 1W0B, 1XZY, 1Y01, 1Z8U, 3IA3
Identifiers
Symbols	AHSP; EDRF; ERAF
External IDs	OMIM: 605821 HomoloGene: 9605 GeneCards: AHSP Gene
Gene Ontology
Molecular function	• protein binding; • hemoglobin binding; • unfolded protein binding;
Cellular component	• cytoplasm; • hemoglobin complex;
Biological process	• protein folding; • hemoglobin metabolic process; • hemopoiesis; • protein stabilization;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Alpha-hemoglobin-stabilizing protein is a protein that in humans is encoded by the ERAF gene.^[1]^[2]^[3]

[edit] References

^ Miele G, Manson J, Clinton M (Mar 2001). "A novel erythroid-specific marker of transmissible spongiform encephalopathies". Nat Med 7 (3): 361–4. doi:10.1038/85515. PMID 11231637.
^ Kihm AJ, Kong Y, Hong W, Russell JE, Rouda S, Adachi K, Simon MC, Blobel GA, Weiss MJ (Jun 2002). "An abundant erythroid protein that stabilizes free alpha-haemoglobin". Nature 417 (6890): 758–63. doi:10.1038/nature00803. PMID 12066189.
^ "Entrez Gene: ERAF erythroid associated factor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51327.

[edit] Further reading

Florio P, Rossi M, Sigurdardottir M et al (2004). "Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A". Steroids 68 (10–13): 801–7. doi:10.1016/S0039-128X(03)00137-5. PMID 14667971.
Weiss MJ, Zhou S, Feng L et al (2006). "Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia". Ann. N. Y. Acad. Sci. 1054: 103–17. doi:10.1196/annals.1345.013. PMID 16339656.
Zhang QH, Ye M, Wu XY et al (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
Gell D, Kong Y, Eaton SA et al (2002). "Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein". J. Biol. Chem. 277 (43): 40602–9. doi:10.1074/jbc.M206084200. PMID 12192002.
Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Viprakasit V, Tanphaichitr VS, Chinchang W et al (2004). "Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia". Blood 103 (9): 3296–9. doi:10.1182/blood-2003-11-3957. PMID 14715623.
Baudin-Creuza V, Vasseur-Godbillon C, Pato C et al (2004). "Transfer of human alpha- to beta-hemoglobin via its chaperone protein: evidence for a new state". J. Biol. Chem. 279 (35): 36530–3. doi:10.1074/jbc.M405389200. PMID 15220346.
Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Gallagher PG, Liem RI, Wong E et al (2006). "GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene". J. Biol. Chem. 280 (47): 39016–23. doi:10.1074/jbc.M506062200. PMID 16186125.
Rual JF, Venkatesan K, Hao T et al (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hamdane D, Vasseur-Godbillon C, Baudin-Creuza V et al (2007). "Reversible hexacoordination of alpha-hemoglobin-stabilizing protein (AHSP)/alpha-hemoglobin Versus pressure. Evidence for protection of the alpha-chains by their chaperone". J. Biol. Chem. 282 (9): 6398–404. doi:10.1074/jbc.M610543200. PMID 17194704.