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Excision repair cross-complementation group 4
Protein ERCC4 PDB 1z00.png
PDB rendering based on 1z00.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ERCC4 ; ERCC11; FANCQ; RAD1; XPF
External IDs OMIM133520 MGI1354163 HomoloGene3836 GeneCards: ERCC4 Gene
RNA expression pattern
PBB GE ERCC4 210158 at tn.png
More reference expression data
Species Human Mouse
Entrez 2072 50505
Ensembl ENSG00000175595 ENSMUSG00000022545
UniProt Q92889 Q9QZD4
RefSeq (mRNA) NM_005236 NM_015769
RefSeq (protein) NP_005227 NP_056584
Location (UCSC) Chr 16:
14.01 – 14.05 Mb
Chr 16:
13.11 – 13.15 Mb
PubMed search [1] [2]

DNA repair endonuclease XPF is an enzyme that in humans is encoded by the ERCC4 gene.[1][2][3]


ERCC4 has been shown to interact with ERCC1[4][5] and FANCA.[6]


  1. ^ Sijbers AM, van Voorst Vader PC, Snoek JW, Raams A, Jaspers NG, Kleijer WJ (Jun 1998). "Homozygous R788W point mutation in the XPF gene of a patient with xeroderma pigmentosum and late-onset neurologic disease". J Invest Dermatol 110 (5): 832–6. doi:10.1046/j.1523-1747.1998.00171.x. PMID 9579555. 
  2. ^ Brookman KW, Lamerdin JE, Thelen MP, Hwang M, Reardon JT, Sancar A, Zhou ZQ, Walter CA, Parris CN, Thompson LH (Dec 1996). "ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs". Mol Cell Biol 16 (11): 6553–62. PMC 231657. PMID 8887684. 
  3. ^ "Entrez Gene: ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4". 
  4. ^ de Laat, W L; Sijbers A M; Odijk H; Jaspers N G; Hoeijmakers J H (Sep 1998). "Mapping of interaction domains between human repair proteins ERCC1 and XPF". Nucleic Acids Res. (ENGLAND) 26 (18): 4146–52. doi:10.1093/nar/26.18.4146. ISSN 0305-1048. PMC 147836. PMID 9722633. 
  5. ^ Park, C H; Sancar A (May 1994). "Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (11): 5017–21. doi:10.1073/pnas.91.11.5017. ISSN 0027-8424. PMC 43921. PMID 8197175. 
  6. ^ Sridharan, Deepa; Brown Monique; Lambert W Clark; McMahon Laura W; Lambert Muriel W (Mar 2003). "Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links". J. Cell. Sci. (England) 116 (Pt 5): 823–35. doi:10.1242/jcs.00294. ISSN 0021-9533. PMID 12571280. 

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