ERCC4

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Excision repair cross-complementation group 4
Protein ERCC4 PDB 1z00.png
PDB rendering based on 1z00.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ERCC4 ; ERCC11; FANCQ; RAD1; XPF
External IDs OMIM133520 MGI1354163 HomoloGene3836 GeneCards: ERCC4 Gene
RNA expression pattern
PBB GE ERCC4 210158 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2072 50505
Ensembl ENSG00000175595 ENSMUSG00000022545
UniProt Q92889 Q9QZD4
RefSeq (mRNA) NM_005236 NM_015769
RefSeq (protein) NP_005227 NP_056584
Location (UCSC) Chr 16:
14.01 – 14.05 Mb
Chr 16:
13.11 – 13.15 Mb
PubMed search [1] [2]

DNA repair endonuclease XPF is an enzyme that in humans is encoded by the ERCC4 gene.[1][2][3]


Interactions[edit]

ERCC4 has been shown to interact with ERCC1[4][5] and FANCA.[6]

References[edit]

  1. ^ Sijbers AM, van Voorst Vader PC, Snoek JW, Raams A, Jaspers NG, Kleijer WJ (Jun 1998). "Homozygous R788W point mutation in the XPF gene of a patient with xeroderma pigmentosum and late-onset neurologic disease". J Invest Dermatol 110 (5): 832–6. doi:10.1046/j.1523-1747.1998.00171.x. PMID 9579555. 
  2. ^ Brookman KW, Lamerdin JE, Thelen MP, Hwang M, Reardon JT, Sancar A, Zhou ZQ, Walter CA, Parris CN, Thompson LH (Dec 1996). "ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs". Mol Cell Biol 16 (11): 6553–62. PMC 231657. PMID 8887684. 
  3. ^ "Entrez Gene: ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4". 
  4. ^ de Laat, W L; Sijbers A M; Odijk H; Jaspers N G; Hoeijmakers J H (Sep 1998). "Mapping of interaction domains between human repair proteins ERCC1 and XPF". Nucleic Acids Res. (ENGLAND) 26 (18): 4146–52. doi:10.1093/nar/26.18.4146. ISSN 0305-1048. PMC 147836. PMID 9722633. 
  5. ^ Park, C H; Sancar A (May 1994). "Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (11): 5017–21. doi:10.1073/pnas.91.11.5017. ISSN 0027-8424. PMC 43921. PMID 8197175. 
  6. ^ Sridharan, Deepa; Brown Monique; Lambert W Clark; McMahon Laura W; Lambert Muriel W (Mar 2003). "Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links". J. Cell. Sci. (England) 116 (Pt 5): 823–35. doi:10.1242/jcs.00294. ISSN 0021-9533. PMID 12571280. 

Further reading[edit]

External links[edit]