ERP29

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Endoplasmic reticulum protein 29
PBB Protein ERP29 image.jpg
PDB rendering based on 1g7e.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ERP29 ; C12orf8; ERp28; ERp31; HEL-S-107; PDI-DB; PDIA9
External IDs OMIM602287 MGI1914647 HomoloGene4963 GeneCards: ERP29 Gene
RNA expression pattern
PBB GE ERP29 201216 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10961 67397
Ensembl ENSG00000089248 ENSMUSG00000029616
UniProt P30040 P57759
RefSeq (mRNA) NM_001034025 NM_026129
RefSeq (protein) NP_001029197 NP_080405
Location (UCSC) Chr 12:
112.45 – 112.46 Mb
Chr 5:
121.43 – 121.45 Mb
PubMed search [1] [2]

Endoplasmic reticulum protein 29 (ERp29) is a chaperone protein that in humans is encoded by the ERP29 gene.[1]

Function[edit]

ERp29 is a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide-isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]

References[edit]

Further reading[edit]