ETFA

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Electron-transfer-flavoprotein, alpha polypeptide
Protein ETFA PDB 1efv.png
PDB rendering based on 1efv.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ETFA ; EMA; GA2; MADD
External IDs OMIM608053 MGI106092 HomoloGene100 GeneCards: ETFA Gene
RNA expression pattern
PBB GE ETFA 201931 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2108 110842
Ensembl ENSG00000140374 ENSMUSG00000032314
UniProt P13804 Q99LC5
RefSeq (mRNA) NM_000126 NM_145615
RefSeq (protein) NP_000117 NP_663590
Location (UCSC) Chr 15:
76.51 – 76.6 Mb
Chr 9:
55.45 – 55.51 Mb
PubMed search [1] [2]

Electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II), also known as ETFA, is a protein which in humans is encoded by the ETFA gene.[1]

ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.[1]

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