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Electron-transfer-flavoprotein, alpha polypeptide
Protein ETFA PDB 1efv.png
PDB rendering based on 1efv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ETFA ; EMA; GA2; MADD
External IDs OMIM608053 MGI106092 HomoloGene100 GeneCards: ETFA Gene
RNA expression pattern
PBB GE ETFA 201931 at tn.png
More reference expression data
Species Human Mouse
Entrez 2108 110842
Ensembl ENSG00000140374 ENSMUSG00000032314
UniProt P13804 Q99LC5
RefSeq (mRNA) NM_000126 NM_145615
RefSeq (protein) NP_000117 NP_663590
Location (UCSC) Chr 15:
76.51 – 76.6 Mb
Chr 9:
55.45 – 55.51 Mb
PubMed search [1] [2]

Electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II), also known as ETFA, is a protein which in humans is encoded by the ETFA gene.[1]

ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.[1]


Further reading[edit]