ETV1

Ets variant 1
Identifiers
Symbols	ETV1; DKFZp781L0674; ER81; MGC104699; MGC120533; MGC120534
External IDs	OMIM: 600541 MGI: 99254 HomoloGene: 3636 GeneCards: ETV1 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • axon guidance • muscle organ development • mechanosensory behavior Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2115	14009
Ensembl	ENSG00000006468	ENSMUSG00000004151
UniProt	P50549	Q549J8
RefSeq (mRNA)	NM_001163147.1	NM_007960
RefSeq (protein)	NP_001156619.1	NP_031986
Location (UCSC)	Chr 7: 13.93 – 14.03 Mb	Chr 12: 39.51 – 39.59 Mb
PubMed search	[1]	[2]

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene.

Further reading

• Monté D, Coutte L, Baert JL, et al. (1995). "Molecular characterization of the ets-related human transcription factor ER81.". Oncogene 11 (4): 771–9. PMID 7651741. 
• Jeon IS, Davis JN, Braun BS, et al. (1995). "A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.". Oncogene 10 (6): 1229–34. PMID 7700648. 
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Carrère S, Verger A, Flourens A, et al. (1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains.". Oncogene 16 (25): 3261–8. doi:10.1038/sj.onc.1201868. PMID 9681824. 
• Coutte L, Monté D, Imai K, et al. (2000). "Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human.". Oncogene 18 (46): 6278–86. doi:10.1038/sj.onc.1203020. PMID 10597226. 
• Janknecht R (2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2.". J. Biol. Chem. 276 (45): 41856–61. doi:10.1074/jbc.M106630200. PMID 11551945. 
• Wu J, Janknecht R (2003). "Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A.". J. Biol. Chem. 277 (45): 42669–79. doi:10.1074/jbc.M205501200. PMID 12213813. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Janknecht R (2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).". Oncogene 22 (5): 746–55. doi:10.1038/sj.onc.1206185. PMID 12569367. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Goel A, Janknecht R (2003). "Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu.". Mol. Cell. Biol. 23 (17): 6243–54. doi:10.1128/MCB.23.17.6243-6254.2003. PMC 180970. PMID 12917345. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=180970. 
• Dowdy SC, Mariani A, Janknecht R (2004). "HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81.". J. Biol. Chem. 278 (45): 44377–84. doi:10.1074/jbc.M307202200. PMID 12947087. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Goel A, Janknecht R (2004). "Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu.". J. Biol. Chem. 279 (15): 14909–16. doi:10.1074/jbc.M400036200. PMID 14747462. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Gocke CB, Yu H, Kang J (2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.". J. Biol. Chem. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718. 

External links

• MeSH ETV1+protein,+human