ETV4

Ets variant 4
Identifiers
Symbols	ETV4; E1A-F; E1AF; PEA3; PEAS3
External IDs	OMIM: 600711 MGI: 99423 HomoloGene: 1504 GeneCards: ETV4 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus • nucleolus Biological process • regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2118	18612
Ensembl	ENSG00000175832	ENSMUSG00000017724
UniProt	P43268	Q3UMZ6
RefSeq (mRNA)	NM_001079675.1	NM_008815.2
RefSeq (protein)	NP_001073143.1	NP_032841.2
Location (UCSC)	Chr 17: 41.61 – 41.62 Mb	Chr 11: 101.63 – 101.65 Mb
PubMed search	[1]	[2]

ETS translocation variant 4 is a protein that in humans is encoded by the ETV4 gene.

Further reading

• Friedman LS, Ostermeyer EA, Lynch ED et al (1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors". Genomics 25 (1): 256–63. doi:10.1016/0888-7543(95)80133-7. PMID 7774926. 
• Liu SH, Peng BH, Ma JT et al (1995). "Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor". Dev. Genet. 16 (3): 229–40. doi:10.1002/dvg.1020160303. PMID 7796532. 
• Friedman LS, Ostermeyer EA, Lynch ED et al (1995). "The search for BRCA1". Cancer Res. 54 (24): 6374–82. PMID 7987831. 
• Higashino F, Yoshida K, Fujinaga Y et al (1993). "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family". Nucleic Acids Res. 21 (3): 547–53. doi:10.1093/nar/21.3.547. PMC 309151. PMID 8441666. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=309151. 
• Urano F, Umezawa A, Hong W et al (1996). "A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma". Biochem. Biophys. Res. Commun. 219 (2): 608–12. doi:10.1006/bbrc.1996.0281. PMID 8605035. 
• Coutte L, Monté D, Baert J, de Launoit Y (2000). "Genomic organization of the human e1af gene,a member of Ets transcription factors". Gene 240 (1): 201–7. doi:10.1016/S0378-1119(99)00400-X. PMID 10564827. 
• Mastrangelo T, Modena P, Tornielli S et al (2000). "A novel zinc finger gene is fused to EWS in small round cell tumor". Oncogene 19 (33): 3799–804. doi:10.1038/sj.onc.1203762. PMID 10949935. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Davidson B, Goldberg I, Gotlieb WH et al (2004). "PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma". Clin. Cancer Res. 9 (4): 1412–9. PMID 12684413. 
• Span PN, Manders P, Heuvel JJ et al (2004). "E1AF expression levels are not associated with prognosis in human breast cancer". Breast Cancer Res. Treat. 79 (1): 129–31. doi:10.1023/A:1023338424677. PMID 12779089. 
• Anderson NL, Polanski M, Pieper R et al (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574. 
• Liu Y, Borchert GL, Phang JM (2004). "Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells". J. Biol. Chem. 279 (18): 18694–700. doi:10.1074/jbc.M308136200. PMID 14976201. 
• Suzuki Y, Yamashita R, Shirota M et al (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316. 
• Davidson B, Goldberg I, Tell L et al (2004). "The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions". Clin. Exp. Metastasis 21 (3): 191–9. doi:10.1023/B:CLIN.0000037703.37275.35. PMID 15387369. 
• Fauquette V, Perrais M, Cerulis S et al (2005). "The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells". Biochem. J. 386 (Pt 1): 35–45. doi:10.1042/BJ20040706. PMC 1134764. PMID 15461591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1134764. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Zhu X, Jiang J, Shen H et al (2005). "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator". J. Biol. Chem. 280 (13): 12503–16. doi:10.1074/jbc.M413631200. PMID 15611127. 
• Takahashi A, Higashino F, Aoyagi M et al (2005). "E1AF degradation by a ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 327 (2): 575–80. doi:10.1016/j.bbrc.2004.12.045. PMID 15629152. 
• Nosho K, Yoshida M, Yamamoto H et al (2005). "Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis". Carcinogenesis 26 (5): 892–9. doi:10.1093/carcin/bgi029. PMID 15695237. 

External links

• MeSH ETV4+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.