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Exocyst complex component 4
Symbols EXOC4 ; SEC8; SEC8L1; Sec8p
External IDs OMIM608185 MGI1096376 HomoloGene40654 GeneCards: EXOC4 Gene
RNA expression pattern
PBB GE EXOC4 gnf1h00385 at tn.png
PBB GE EXOC4 gnf1h01429 s at tn.png
More reference expression data
Species Human Mouse
Entrez 60412 20336
Ensembl ENSG00000131558 ENSMUSG00000029763
UniProt Q96A65 O35382
RefSeq (mRNA) NM_001037126 NM_009148
RefSeq (protein) NP_001032203 NP_033174
Location (UCSC) Chr 7:
132.94 – 133.75 Mb
Chr 6:
33.25 – 33.97 Mb
PubMed search [1] [2]

Exocyst complex component 4 is a protein that in humans is encoded by the EXOC4 gene.[1][2][3]


The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]


EXOC4 has been shown to interact with:


  1. ^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  2. ^ a b c Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (Apr 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature 422 (6932): 629–33. doi:10.1038/nature01533. PMID 12687004. 
  3. ^ a b "Entrez Gene: EXOC4 exocyst complex component 4". 
  4. ^ a b c d e Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C et al. (Jun 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. 5 (6): 520–30. doi:10.1038/ncb990. PMID 12738960. 
  5. ^ Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL (Jul 2003). "Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor)". Biochem. J. 373 (Pt 1): 49–55. doi:10.1042/BJ20021838. PMC 1223477. PMID 12675619. 

Further reading[edit]