EXOC8

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Exocyst complex component 8
Protein EXOC8 PDB 1zc3.png
PDB rendering based on 1zc3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EXOC8 ; EXO84; Exo84p; SEC84
External IDs OMIM615283 MGI2142527 HomoloGene44545 GeneCards: EXOC8 Gene
Orthologs
Species Human Mouse
Entrez 149371 102058
Ensembl ENSG00000116903 ENSMUSG00000074030
UniProt Q8IYI6 Q6PGF7
RefSeq (mRNA) NM_175876 NM_198103
RefSeq (protein) NP_787072 NP_932771
Location (UCSC) Chr 1:
231.47 – 231.47 Mb
Chr 8:
124.89 – 124.9 Mb
PubMed search [1] [2]

Exocyst complex component 8 is a protein that in humans is encoded by the EXOC8 gene.[1][2]

Interactions[edit]

EXOC8 has been shown to interact with RALB.[3]

References[edit]

  1. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS et al. (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  2. ^ "Entrez Gene: EXOC8 exocyst complex component 8". 
  3. ^ Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L et al. (Dec 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976. 

Further reading[edit]

  • Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH (1998). "Subunit structure of the mammalian exocyst complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14438–43. doi:10.1073/pnas.94.26.14438. PMC 25013. PMID 9405631. 
  • Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH (1998). "Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments". Neuron 20 (6): 1111–22. doi:10.1016/S0896-6273(00)80493-6. PMID 9655500. 
  • Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J. Biol. Chem. 276 (32): 29792–7. doi:10.1074/jbc.C100320200. PMID 11406615. 
  • Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature 422 (6932): 629–33. doi:10.1038/nature01533. PMID 12687004. 
  • Wang S, Hsu SC (2004). "Immunological characterization of exocyst complex subunits in cell differentiation". Hybrid. Hybridomics 22 (3): 159–64. doi:10.1089/153685903322286575. PMID 12954101. 
  • Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.