Although the exact sign-on date of WXXV-DT2 is unknown, the station began carrying MyNetworkTV programming at the service's inception on September 5, 2006. MyNetworkTV was a response to The WB and UPN merging their operations in order to form a new network, The CW. Around the same time of network partners CBS and the Warner Bros. unit of Time Warner announcing the consolidation, News Corporation (owner of Fox) made public that it too was establishing a new programming service known as MyNetworkTV. It was specifically created for television stations formally affiliated with The WB or UPN that were supposedly not announced as joining The CW in addition to offering competition on new stations.
As a MyNetworkTV outlet, WXXV-DT2 serves as the Hattiesburg/Laurel market's default affiliate since that area lacks a locally-associated station. Its over-the-air digital signal originates from a transmitter that is strategically located and features a directional antenna pattern to enable the station to cover all locations in Mississippi's Gulf Coast and Pine Belt regions.
It has been announced that in late-June 2012, MyNetworkTV will revert to cable-exclusive status joining local CW Plus outlet "WBGP" that is also only seen on cable. The change will then allow WXXV-DT2 to become the market's first ever NBC affiliate. Even though the outlet is already seen in 720p high definition over-the-air, it is unknown if the service would be upgraded to NBC's normal 1080i broadcast format.
Corresponding with the announcement of NBC coming to WXXV-DT2, station owner Morris Multimedia made public its plans to bring back an in-house local news operation for the second time in WXXV's history. A previous attempt for a few years in the late-1990s and early-2000s was ultimately scrapped. After expanding its studios and hiring personnel, newscasts will air in high definition from a newly built set on this subchannel. No exact date for the news operation launch has been made yet.