From Wikipedia, the free encyclopedia
Jump to: navigation, search
Skeletal formula of ebselen
Ball-and-stick model of the ebselen molecule
CAS number 60940-34-3 YesY
PubChem 3194
ChemSpider 3082 YesY
ChEBI CHEBI:77543 YesY
Jmol-3D images Image 1
Image 2
Molecular formula C13H9NOSe
Molar mass 274.17666
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite.[1] It is being investigated as a possible treatment for reperfusion injury and stroke,[2][3] hearing loss and tinnitus,[4] and bipolar disorder.[5][6]

Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.


  1. ^ Schewe T (1995). "Molecular actions of ebselen--an antiinflammatory antioxidant". Gen Pharmacol 26 (6): 1153–69. doi:10.1016/0306-3623(95)00003-J. PMID 7590103. 
  2. ^ Parnham M, Sies H (2000). "Ebselen: prospective therapy for cerebral ischaemia". Expert Opin Investig Drugs 9 (3): 607–19. doi:10.1517/13543784.9.3.607. PMID 11060699. 
  3. ^ Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H (1 January 1998). "Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group". Stroke 29 (1): 12–7. doi:10.1161/01.STR.29.1.12. PMID 9445321. 
  4. ^ Kil, Jonathan; Pierce, Carol; Tran, Huy; Gu, Rende; Lynch, Eric D (2007). "Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase". Hearing Research 226 (1–2): 44–51. doi:10.1016/j.heares.2006.08.006. PMID 17030476. 
  5. ^ Singh, N.; Halliday, A. C.; Thomas, J. M.; Kuznetsova, O. V.; Baldwin, R.; Woon, E. C. Y.; Aley, P. K.; Antoniadou, I.; Sharp, T.; Vasudevan, S. R.; Churchill, G. C. (2013). "A safe lithium mimetic for bipolar disorder". Nature Communications 4: 1332. doi:10.1038/ncomms2320. PMC 3605789. PMID 23299882.  edit
  6. ^ "New drug for bipolar disorder may offer fewer side effects". University of Oxford Latest News. 2013-01-08. Retrieved 12 January 2013.