Eccrine sweat gland

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Eccrine sweat gland
Gray940 - sweat gland.png
A sectional view of the skin (magnified), with eccrine glands highlighted.
Latin Glandula sudorifera merocrina;
Glandula sudorifera eccrina
System Integumentary[1]
Nerve Cholinergic sympathetic nerves[2]
Precursor Ectoderm[1]
MeSH Eccrine+Glands
Code TH H3.

Eccrine glands (/ˈɛkrən/, /ˈɛˌkrn/, or /ˈɛˌkrin/; from ekkrinein "secrete";[3] sometimes called merocrine glands) are the major sweat glands of the human body, found in virtually all skin.[4] They produce a clear, odorless substance, consisting primarily of water and NaCl (note that the odor from sweat is due to bacterial activity on the secretions of the apocrine sweat glands). NaCl is reabsorbed in the duct to reduce salt loss.[5] They are active in thermoregulation and emotional sweating (induced by anxiety, fear, stress, and pain).[6]:170. The white sediment in otherwise colorless eccrine secretions is caused by evaporation that increases the concentration of salts.

Eccrine glands are composed of an intraepidermal spiral duct, the "acrosyringium"; a dermal duct, comprising a straight and coiled portion; and a secretory tubule, coiled deep in the dermis or hypodermis.[6]:172 Eccrine glands are innervated by the sympathetic nervous system, primarily by cholinergic fibers, but by adrenergic fibers as well.[7]

Dermcidin is a newly isolated antimicrobial peptide produced by the eccrine sweat glands.[8]


  1. ^ a b Neas, John F. "Development of the Integumentary System". In Martini, Frederic H.; Timmons, Michael J.; Tallitsch, Bob. Embryology Atlas (4th ed.). Benjamin Cumings. Retrieved 17 December 2012. 
  2. ^ Krstic, Radivoj V. (18 March 2004). Human Microscopic Anatomy: An Atlas for Students of Medicine and Biology. Springer. p. 464. ISBN 9783540536666. 
  3. ^ "eccrine". The New Oxford American Dictionary (2 ed.). 2005. ISBN 9780195170771. 
  4. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. pp. 6–7. ISBN 0-7216-2921-0. 
  5. ^ Mauro, Theodora M; Goldsmith, Lowell A. "Biology of Eccrine, Apocrine, and Apoeccrine Sweat Glands". In Wolff, K; Goldsmith, LA; Katz, SI; Gilchrest, B; Paller, AS; Leffell, DJ. Fitzpatrick's Dermatology in General Medicine. 
  6. ^ a b Wilke, K.; Martin, A.; Terstegen, L.; Biel, S. S. (June 2007). "A short history of sweat gland biology" (pdf). International journal of cosmetic science 29 (3): 169–179. doi:10.1111/j.1467-2494.2007.00387.x. ISSN 1468-2494. 
  7. ^ Sokolov, VE; Shabadash, SA; Zelikina, TI (1980). "Innervation of eccrine sweat glands". Biology Bulletin of the Academy of Sciences of the USSR 7 (5): 331–46. PMID 7317512. 
  8. ^ Niyonsaba, F; Suzuki, A; Ushio, H; Nagaoka, I; Ogawa, H; Okumura, K (2009). "The human antimicrobial peptide dermcidin activates normal human keratinocytes". The British journal of dermatology 160 (2): 243–9. doi:10.1111/j.1365-2133.2008.08925.x. PMID 19014393. 

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