|Jmol-3D images||Image 1|
|Molar mass||1060.24 g/mol|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Echinocandin B, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called Echinocandins, which inhibits the synthesis of glucan, a major component of the fungal cell wall, via noncompetitive inhibition of a crucial enzyme, β-(1,3)-D-glucan synthase. Echinocandin B is a fermentation product of Aspergillus nidulans and the closely related species, Aspergillus rugulosus; discovered in 1974 in Aspergillus nidulans var. echinulatus strain A 32204 in Germany, it was the first of the echinocandin class of antifungals.
Echninocandin B can undergo deacylation (removal of the lipid side-chain) by the action of a deacylase enzyme from the bacteria Actinoplanes utahensis, which catalyzes the cleavage of the linoleoyl side chain; in three subsequent synthetic steps, including a chemical reacylation, the antifungal drug anidulafungin is synthesized.
- Denning DW (1997). "Echinocandins and pneumocandins - a new antifungal class with a novel mode of action". J Antimicrob Chemother 40: 611–614. doi:10.1093/jac/dkf045.
- Nyfeler R, Keller-Schierlein W (1974). "Metabolites of microorganisms. 143. Echinocandin B, a novel polypeptide-antibiotic from Aspergillus nidulans var. echinulatus: isolation and structural components". Helv Chim Acta 57 (8): 2459–2477. doi:10.1002/hlca.19740570818. PMID 4613708.
- Lei Shao, Jian Li, Aijuan Liu, Qing Chang, Huimin Lin, Daijie Chen (2013). "Efficient Bioconversion of Echinocandin B to Its Nucleus by Overexpression of Deacylase Genes in Different Host Strains". Applied and Environmental Microbiology 79 (4): 1126–1133. doi:10.1128/AEM.02792-12. PMID 23220968.
- "Anidulafungin EMA Europa".
|This article about an organic compound is a stub. You can help Wikipedia by expanding it.|